High Fat Rodent Models of Type 2 Diabetes: From Rodent to Human
نویسندگان
چکیده
منابع مشابه
Remodeling rodent models to mimic human type 1 diabetes.
Type 1 diabetes (T1D) occurs when the immune system attacks the insulin-producing beta cells located in the islets of Langerhans within the pancreas. Animal models have played a prominent role in developing an understanding of this disease process, through studies of genetic susceptibility, progression of hyperglycemia, and novel approaches to therapy. Here, we critically evaluate the currently...
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Diabetes mellitus, especially type 2 diabetes (T2DM), is one of the most common chronic diseases and continues to increase in numbers with large proportion of health care budget being used. Many animal models have been established in order to investigate the mechanisms and pathophysiologic progress of T2DM and find effective treatments for its complications. On the basis of their strains, featu...
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The rats listed here have been extensively studied as animal models of diabetic complications and their pathogenesis. The results of studies with the SHROB, JCR:LAcp and OLETF rats are instructive in understanding macro vascular diseases. The Cohen, GK, SHROB and OLETF rats are model of diabetic kidney disease. The SHROB rat might also be useful for diabetic retinopathy study. The importance of...
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Type 1 diabetes (T1D) is characterized by hyperglycemia due to lost or damaged islet insulin-producing β -cells. Rodent models of T1D result in hyperglycemia, but with different forms of islet deterioration. This study focused on 1 toxin-induced and 2 autoimmune rodent models of T1D: BioBreeding Diabetes Resistant rats, nonobese diabetic mice, and Dark Agouti rats treated with streptozotocin. I...
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ژورنال
عنوان ژورنال: Nutrients
سال: 2020
ISSN: 2072-6643
DOI: 10.3390/nu12123650